An efficient protocol for copper-free palladium-catalyzed Sonogashira cross-coupling in aqueous media at low temperatures

An efficient protocol for copper-free palladium-catalyzed Sonogashira cross-coupling in aqueous media at low temperatures

An efficient protocol for copper-free palladium-catalyzed Sonogashira cross-coupling in aqueous media at low temperatures
A.N. Marziale, J. Schlüter, J. Eppinger
Tetrahedron Letters, Volume 52, Issue 48, Pages 6355-6358, (2011)
A.N. Marziale, J. Schlüter, J. Eppinger
Cross-coupling, Palladacycle, Sonogashira, Sustainability
2011
A thorough study on copper-free Sonogashira cross-couplings in water was carried out using the palla-dacycle,
[{Pd(μ-Cl){K2-P,C-P(iPr)2(OC6H3-2-Ph)}}2] as pre-catalyst with different bases and palladium concentrations. The highly active pre-catalyst imparts good to near quantitative yields using a concentration of 0.25 mol % at 40 °C. This broadly applicable protocol exhibits high tolerance of functional groups and substitution patterns.
 
 
 
10.1016/j.tetlet.2011.09.031
00404039