Phenylalanine-a biogenic ligand with flexible η6- and η6:κ1-coordination at ruthenium(II) centres

Phenylalanine-a biogenic ligand with flexible η6- and η6:κ1-coordination at ruthenium(II) centres

Phenylalanine-a biogenic ligand with flexible η6- and η6:κ1-coordination at ruthenium(II) centres
T. Reiner, D. Jantke, D.b, X.-H. Miao, A.N. Marziale, F.J. Kiefer, J. Eppinger
Dalton Transactions, Volume 42, Issue 24, 28, Pages 8692-8703, (2013)
T. Reiner, D. Jantke, D.b, X.-H. Miao, A.N. Marziale, F.J. Kiefer, J. Eppinger
Basic conditions, Biogenic ligands, Coordination sphere, Ethyl esters, Ethylene diamine, Metal centres, Ruthenium chlorides
2013

The reaction of (S)-2,5-dihydrophenylalanine 1 with ruthenium(III) chloride yields the μ-chloro-bridged dimeric η6-phenylalanine ethyl ester complex 3, which can be converted into the monomeric analogue, η61-phenylalanine ethyl ester complex 12, under basic conditions. Studies were carried out to determine the stability and reactivity of complexes bearing η6- and η6: κ1-chelating phenylalanine ligands under various conditions. Reaction of 3 with ethylenediamine derivatives N-p-tosylethylenediamine or 1,4-di-N-p-tosylethylenediamine results in the formation of monomeric η61-phenylalanine ethyl ester complexes 14 and 15, which could be saponified yielding complexes 16 and 17 without changing the inner coordination sphere of the metal centre. The structure of η61-phenylalanine complex 17 and an N-κ1-phenylalanine complex 13 resulting from the reaction of 3 with an excess of pyridine were confirmed by X-ray crystallography.




10.1039/c3dt50589h

14779226