Hybrid biocatalysts for fine chemical and bio-polymer production

Hybrid biocatalysts for fine chemical and bio-polymer production

Details

​Integrating the specific advantages of organometallic and bio–catalysis, the concept of organometallic enzyme hybrids (OMEHs) is developed and utilized in selective hydrogenation, cross–coupling and polymerization reactions. The hybrid catalysts are created through linkage of artificial and catalytically active cofactors or introduction of unnatural amino acids based on an expanded genetic code. Enzyme hybrids are optimized by a combination of in silico design and directed evolution.

Collaborators

​​Collaborating partners in this multidisciplinary approach are Peter G. Schultz (Scripps) and Michael Groll (TUM).

Publications

Key references: 1) Organometallics 2008, 27, 736; 2) J. Organomet. Chem. 2008, 693, 2223; 3) Inorg. Chem. 2009, 48, 3699; 4) J. Organomet. Chem. 2010, 695, 2667.